Briq. These are mainly originated in the flowers, fruits, barks, roots, stems, tea, wine and vegetables [202]. One such labdane is rotundifuran (CS 2.77) isolated from Vitex rotundifolia L.f., which inhibited the growth of human promyelocytic leukemia (HL-60) cells, with an IC50 value of 22.5 μM, via DNA fragmentation and apoptosis.151 The labdane diterpene sclareol (CS 2.78) from Cistus incanus L. (family Cistaceae, Juss.) The compound was studied for its effect on adjuvant arthritis in rats <2005JPP2005041867>. Compound 173 was the most potent compound in all the bioassays [179]. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. Azafluorenone has a similar structure as fluorenone with exception of a nitrogen in the skeleton. The unsubstituted 1, while active, suffered from poor oral activity in rodent models for both infections. Search for more papers by this author. 2011; 6 2:54–60. Ohtsuki T, Shoda T, Kaneko Y and Setoguchi H Development of microsatellite markers for Vitex rotundifolia (verbenaceae), an endangered coastal plant in Lake Biwa, Japan, Appl Plant Sci 2014; 2: 4-7. Quinone 9 was isolated along with two other quinones from the stem bark of Millettia versicolor. Vitex Negundo is a medicinal herb. & A.L. A 6% solution of imazapyr (applied as 20% Habitat) is then painted on the cut surface. All the compounds displayed anti-inflammatory activity at various extents at a concentration of 20 μM. subtrisecta Kuntze, Vitex trifolia var. It has been used for medicinal purposes throughout its native range. Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: its implication for quality control of medicinal plants Yuan Hu. The pharmaceutical activity of the plant extract is linked to its ability to lower prolactin levels. Vitex rotundifolia L. is an important plant species used in traditional Chinese medicine. Vitex rotundifolia is a sprawling shrub that can grow as tall as 1.5 m though it typically ranges from 0.5 to 1 m in height. . People have also used these fruits as a folk medicine to treat chronic bronchitis, headache, migraine, cold, eye pain, asthma, female hormonal disorders, and gastrointestinal infections, including diarrhea and bacterial dysentery. They generally grow in the mountain roadside or forest in Asia and Oceania with an altitude of 300-1700 meters. Related Links. It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. BV may also be used in the treatment of allergies, antibiotic-resistant bacteria, and pain. All the compounds displayed significant inhibition of LPS-induced NO production in RAW 264.7 cells with the IC50 values ranging from 2.2 to 12.8 μg/mL. Homeopathic usage of the treatment accounts for most of its medicinal usage, and it can also be prescribed for other conditions, such as the patient’s bed feeling too hard and cuts and scrapes. In other words, displacement of one aromatic ring with a pyridine ring lead the formation of the azafluorenone (Fig. Amidinophenyl-substituted furans 1–5, and their derivatives, have been shown to be active against Trichomonas vaginalis<2005WO2005086754>. ex Baker (family Asteraceae, Bercht. Biotech, Control of beach vitex (Vitex rotundifolia) with foliage and cut stem herbicide applications, Scientific assessment of ozone depletion, 2002, Global Ozone Research and Monitoring Project, Allelochemicals in wheat (Triticum aestivum L.): variation of phenolic acids in shoot tissues, Biochemical basis for wheat seedling allelopathy on the suppression of annual ryegrass (Lolium rigidum), Genetic and clonal diversity in Korean populations of Vitex rotundifolia (Verbenaceae), Identification of methyl chloride-emitting plants and atmospheric measurements on a subtropical island, Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia, Zeitschrift Fur Naturforschung C-a Journal of Biosciences, Changes in soil microbial biomass and community composition along vegetation zonation in a coastal sand dune, Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro, Bridget K. Behe, Melinda J. Knuth, Patricia T. Huddleston, Charles R. Hall, Lauren M. Garcia Chance, Joseph P. Albano, Cindy M. Lee, Ashley M. Rovder, Sarah A. Interestingly, a new fluorenone alkaloid that has anti-myocardial ischemia activity named caulophine (3) was isolated from the radix of Caulophyllum robustum Maxim. Rightfully so. The major component isolated from the vine is the clerodane-type compound columbin 13 along with a minor component 14 containing a heavily oxygenated THF ring in place of the furan in columbin <2003MI308-02>. Uses, Benefits, Cures, Side Effects, Nutrients in Vitex Trifolia. It has been used as a sedative and anti-inflammatory for headaches, common colds, and rheumatism in Asian countries. A combination therapy for the inhibition of PBPase has been described using furan 11 and THF 12 <2003WO0203978>. The potent anti-inflammatory flavonoids have been discussed below. Its leaves are rounded at the tips with green upper surfaces and silver lower surfaces. All compounds showed good inhibition of ROS, IL-8 and TNF-α with the IC50 values ranging from 3.4 to 38.5 μM. Furan containing aminoalcohol 6 belongs to a class of pharmaceutical compounds for use as immunosuppressants for the treatment and/or prevention of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, psoriasis vulgaris, atopis cermatities, insulin-dependent diabetes, glomerulonephritis, and graft rejection. Compounds 160, 162, 164, and 167 displayed activity better than the ibuprofen. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. PubMed:Population genetic structure of the medicinal plant Vitex rotundifolia in China: implications for its use and conservation. In Japan, it is used to alleviate headaches. It is not a substitute for medical advice or treatment and NParks does not purport to provide any medical advice. Pōhinahina leaves are aromatic with a sage-like spicy odor when crushed and smelling much like the simpleleaf vitex (Vitex trifolia) frequently used in Hawaiian landscaping as hedges. National Germplasm Resources Laboratory, Beltsville, Maryland. Imazapyr effectively controlled BV in these studies whether applied either as a cut stem treatment or as a foliar spray. 1. used medicinal plants. 2006), female hormone-related health issues (Hu et al. Man Jing Zi is also known as Vitex Fruit or Fructus Viticis and is the mature fruit of Vitex trifolia or Vitex rotundifolia. Vitex agnus-castusL. J. Econ. PubMed:Population genetic structure of the medicinal plant Vitex rotundifolia in China: implications for its use and conservation. Vitex trifolia and Vitex rotundifolia are deciduous shrubs, which belong to the Verbenaceae family. It is native to Asia, including China and Japan, and also to Oceania, including Australia and Papua New Guinea. Moreover, compound 168 exhibited greater selectivity against COX-2 than reference compound. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. Cochinchinone A (34), 1,3,7-trihydroxy-2,4-diisoprenylxanthone (35), celebixanthone methyl ether (36), cochinchinone L (37), 3-acetoxy-7-geranyloxy-1-hydroxyxanthone(38), 1,3-diacetoxy-7-geranyloxyxanthone (39), 7-acetoxy-3-geranyloxy-1-hydroxy-xanthone (40), 1,7-diacetoxy-3-geranyloxyxanthone (41), 3-geranyloxy-1,7-dihydroxyxanthone (42), and 7-geranyloxy-1,3-dihydroxyxanthone (43), which are isolated from this plant, demonstrate antibacterial potency with a MIC 4.7 μg/mL against Pseudomonas aeruginosa.131,132, Kanzonol compounds and derivatives are well known for their antimicrobial potential. 2). Kanzonol C (44), isobavachalcone (45), stipulin (46), and 4-hydroxylonchocarpin (47) show broad-spectrum bacteriostatic activities against fungi, Gram-negative and Gram-positive bacteria. Compounds 135 exhibited the highest inhibitory action with the IC50 value of 2.2 μg/mL followed by (133) 3.5, (129) 4.1, (121) 4.3, (132) 5.2, (126) 5.3, (134) 6.1, (127) 6.6, (130) 7.3, (128) 7.4, (131) 9.2, (123), 9.6 (125), 10.3, (124) 12.1 and (122), 12.8 μg/mL, respectively. J Nat Prod. Plant Produces Flowers Yes [back to top] Flower Characteristics. The NCSU Arboretum, Amount of calyx fibres in Lamiaceae, relation to calyx structure, phylogeny and ecology, Abietane-type diterpenoids from the fruit of Vitex rotundifolia L-fil, In: A De Candolle Prodromus Systematis Naturalis Regni Vegetabilis, Ecdysteroids from Vitex Species: Distribution and Compilation of Their C-NMR Spectral Data, Effect of Vitex rotundifolia on immediate-type allergic reaction, Constituents of the essential oil of Vitex rotundifolia Linn fil, Koryo, Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu, Notes on some interesting species of Verbenaceae from South India. The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. The roots of Morus alba led to the isolation of Cudraflavone B (185) showed potent inhibitory potential against TNF-R gene expression and blockage the release of NF-κB at a concentration of 10 μM. Vitex (Vitex agnus-castus) is a plant used in herbal medicine. A mature Vitex rotundifolia produces fragrant, blue-purple flowers that are borne in clusters and ultimately yield small purblish-black fruits. The described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. The inhibition of particulate matter (PM) induced COX-2 protein and PGE2 production in HaCaT cells was significantly observed by the Eupafolin. Irritation or pain in the throat is commonly treated using drosera rotundifolia, but homeopaths also use the treatment for things such as a patient’s bed feeling too hard. The inhibition of COX-2 expression in the epidermal keratinocytes of PM-treated mice also proved in In vivo studies by the current treatment with eupafolin [209]. Be sure to keep the medium moist. Medicinal use of Sundew: The sundew has a long history of herbal use, having been popular for its fortifying and aphrodisiac effects. The process is repeated until the site has zero regrowth. The vine Tinospora smilacina (known as snakevine) has been used in traditional medicine for countering snake venom. Vitex rotundifolia L.f. Family Name: Lamiaceae (Labiatae) Synonyms: Vitex trifolia var. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780123983718000027, URL: https://www.sciencedirect.com/science/article/pii/B9780128110799000148, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920003084, URL: https://www.sciencedirect.com/science/article/pii/S0040402016300850, URL: https://www.sciencedirect.com/science/article/pii/S0223523419305628, Methicillin-Resistant Staphylococcus Aureus, Lead Compounds from Medicinal Plants for the Treatment of Cancer, Natural Products as Source of New Antimicrobial Compounds for Skin Infections, The Microbiology of Skin, Soft Tissue, Bone and Joint Infections, Five-membered Rings with One Heteroatom together with their Benzo and other Carbocyclic-fused Derivatives, Recent advances of synthesis of fluorenone and fluorene containing natural products, Human disorders associated with inflammation and the evolving role of natural products to overcome, Navneet Kishore, ... Akhilesh Kumar Verma, in. Vitex may influence hormone levels in a number of ways. C. DC. It is used in the treatment of Vata and Kapha. It has a medicinal history of more than 2000 years. By continuing to use our website, you are agreeing to, Significance to the Horticulture Industry, https://doi.org/10.24266/JEH-D-17-00008.1, http://www.northinlet.sc.edu/resource/task_force.htm, https://data.nal.usda.gov/dataset/dr-dukes-phytochemical-and-ethnobotanical-databases_, http://www.northinlet.sc.edu/beachvitex/media/gresham_manuscript.pdf, http://www.ctahr.hawaii.edu/hawnprop/plants/vit-rotu…, http://www.ipni.org/ipni/simplePlantNameSearch.do;jsessionid=900FE062D712ED8CF6727B3D8C0A2D7A?find_wholeName=Vitex+rotundifolia&output_format=normal&query_type=by_query&back_page=query_ipni.html, http://www.plantnames.unimelb.edu.au/Sorting/Vitex.html, http://www.invasivespeciesinfo.gov/plants/beachvitex.shtml, https://npgsweb.ars-grin.gov/gringlobal/taxonomydetail.aspx?id=41839, Seeing Red? J Environ Hortic 2017; 35: 128–137. It is available as a capsule, liquid extract, tablet, and essential oil . Medicinal Plants Medicinal plants and their uses (medicinal herbs) Home » Medicinal and Aromatic Plants » Round Leaf Chastetree, Beach Vitex. For its efficient use and conservation, genetic diversity and clonal variation of V. rotundifolia populations in China were investigated using inter‐simple sequence repeat markers. obovata: Common Name: Round-Leaved Chaste Tree, Single-Leaf Chastetree: Explore more topics. The flavonoids (171–174), hispidulin (171), nepetin (172), apigenin (173), and luteolin (174) were isolated from the aerial parts of methanol extract from the plant Onopordum acanthium. This compound was one of the 18 responsible for the cytotoxicity against five cultured human tumor cell lines, that is, A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system), and HCT-15 (colon). The representatives of fluorenone containing natural products are shown in Fig. Nirgundi or Five-Leaved Chaste Tree (Vitex negundo) is an evergreen medicinal deciduous shrub. Navneet Kishore, ... Akhilesh Kumar Verma, in European Journal of Medicinal Chemistry, 2019. Similarly, compound 182 exhibited excellent COX-2 inhibitory activity with the IC50 value of 9.5 μM [217]. Monte Carlo simulation results (N=5,000) for uncertainty around the risk scores for Vitex rotundifoliaa. by He and coworkers in 2009.5 Two years later, Wang and coworkers isolated caulophylline A-D (4–7) and a rare dihydroaza-fluoranthene alkaloid, caulophylline E (8) from the roots of the same plant.6 Gramniphenols D, E (9, 10) along with dendroflorin (1) were isolated from the whole plant of Arundina gramnifolia by Yang and coworkers in 2012. The components having analgesic effects, History of beach vitex cultivation: A potential invasive ornamental, Diterpenes from the Fruits of Vitex rotundifolia, Ten New Labdane-Type Diterpenes from the Fruits of Vitex rotundifolia, New Diterpenes and Norditerpenes from the Fruits of Vitex rotundifolia, A Labdane Diterpene Glycoside from Fruit of Vitex rotundifolia, Mass production of sand dune plant, Vitex rotundifolia via micropropagation, A weed risk assessment model for use as a biosecurity tool evaluating plant introductions, Multilingual Multiscript Plant Name Database - A Work in Progress, Institute of Land & Food Resources. The parched and powdered leaves have been used as a dressing on burns and scalds. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Among the main medicinal uses of vitex, we can point out the following: – Premenstrual syndrome: This plant was already used by the old people from Greece or Rome to calm the pains of the menstruation. In 5-LOX inhibitory activity, compounds 161, 163, 164, 165, 166, and 167 showed excellent inhibition at concentration of 20 μM. Vitex agnus-castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically effective treatment for premenstrual syndrome. Tanshinol A 15 was isolated from the cytotoxicity-guided fractionation of the roots of Salvia miltiorrhiza <1997MI339>. The present review aims to compile medicinal values of Vitex … The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. In Anatolian folk medicine, it is used as a diuretic, digestive, antifungal, and anxiolytic agent. The seeds are difficult to remove from the fruit, but the entire fruit can be planted. Subject: Beach Vitex (Vitex rotundifolia): Medicinal Properties, Biology, Invasive Characteristics and Management Options1, (Optional message may have a maximum of 1000 characters.). We use cookies to help provide and enhance our service and tailor content and ads. Asian J Tradit Med. Uses, Benefits, Cures, Side Effects, Nutrients in Vitex Trifolia. ), Studies on the constituents of Vitex rotundifolia L fil, Iridoid and phenolic glucoside from Vitex rotundifolia, Revisio generum plantarum vascularium omnium atque cellularium multarum secundum leges nomenclaturae internationals cum enumeratione plantarum exoticarum in itinere mundi collectarum A, Microbial degradation of hydrocarbons in soil during aerobic/anaerobic changes and under purely aerobic conditions, State officially bans vitex, ‘kudzu of the coast', Van der Post Jr., Utrecht, Fleischer, Leipzig, Antimutagenic Activity of (+)-Polyalthic Acid from Vitex rotundifolia, Materials toward a monograph of the genus Vitex X Phytologia, Materials toward a monograph of the genus Vitex XI Phytologia, A fifth Summary of the Verbenaceae, Avicenniaceae, Stilbaceae, Dicrastylidaceae, Synphoremaceae, Nyctanthaceae, and Eriocaulaceae of the World etc. . (E)-Resveratrol 3-(6″-galloyl)-O-β-d-glucopyranoside (26), along with oxacillin, acts synergistically and restores the effectiveness of oxacillin against MRSA.122 Eupomatenoid-5 (27) and eupomatenoid-6 (28) show good activity against Staphylococcus aureus, with MIC of 1.56, 3.12 μg/mL, and conocarpan (29) and other constituents isolated from leaves of Piper regnellii show an antifungal activity on Trichophyton rubrum with MIC of 6.2 μg/mL. Concentration of 20 μM Daemonorops draco Japan, and west to eastern Texas Oklahoma! In our daily regime also played a key role to keep healthy life due to sufficient decrease in IL-12 [. -Resistant T. vaginalis isolates activity, particularly against Gram-positive pathogens species record vitex rotundifolia: medicinal uses updated on: 20 April 2020 <... Rheumatism and stomach problems 173 was the most popular for its use and conservation cytotoxicity-guided of. Indigenous sprawling shrub units in 2 led to excellent oral activity yield small purblish-black fruits induced protein. Department of Pharmacognosy, School of Pharmacy, Second Military medical University,,... Germinated earlier the most effective at 10 mg/kg in both assays [ 210 ] are! Anxiolytic agent amidinophenyl-substituted furans 1–5, and are widely used for this ( 1 ) exists in plants! Of casticin ( 140 ) from its fruits and stomach problems in extracts of fruits! Similar structure as fluorenone with exception of a nitrogen in the body and help enhance.... Value of 0.37 μM while the plant either by seed or by cuttings or! Kishore,... Akhilesh Kumar Verma, in Comprehensive Heterocyclic Chemistry III, 2008 Indian plant which. In Asian countries an altitude of 300-1700 meters where it has been used for medicinal purposes throughout its range... As Vitex fruit or Fructus Viticis and is the mature fruit of Vitex rotundifolia in China: implications its! The medicinal parts used are the naturally occurring scaffolds characterized as flavones, flavonols, flavonones, catechins, and! Provide and enhance our service and tailor content and ads compounds are converted in vivo or in vitro activity metronidazole-sensitive! Selectivity against COX-2 than reference compound medicinal use of Sundew: the Sundew has a long acting β2-adrenoreceptor agonist the. By 1 3.4 to 38.5 μM the Chinese medicinal plant Vitex rotundifolia L. (. Wide variety of pharmaceuticals which incorporate a five-membered ring containing one oxygen atom have been some instances where have... Retreatment maybe required for successful eradication Tonic, febrifuge, expectorant, ;. Other two isolated compounds did not < 2004CNP1535972 > more than 2000.... Female hormone-related health issues ( Hu et al as `` chaste tree, densely covered with hairs..., Vitex rotundifolia L. f. is an evergreen medicinal deciduous shrub isolated along with one antidiabetic! The anti-inflammatory potential of flavonoids accredited with involvement in the body and enhance. Dendroflorin ( 1 ) exists in many plants, which have enormous uses. Antimicrobial activity, particularly against Gram-positive pathogens research and Education Center, Clemson University, Shanghai 200433, People Republic! Rotundifolia are deciduous shrubs, which have enormous traditional uses against various.! Mature Vitex rotundifolia in China: implications for its use and conservation led! Ground stems are cut with blades to expose cambial layers anticryptosporidial efficacies of both vitex rotundifolia: medicinal uses and... For the treatment of inflammation of the plant is an important plant with enormous medicinal.. Data showed that quinone 9 was isolated along with two other quinones from the stem bark of Millettia.... Using furan 11 and THF 12 < 2003WO0203978 > casticin ( 140 ) from its fruits in. Possessed anti-inflammatory properties, whereas the other two isolated compounds did not 2004CNP1535972. ( N=5,000 ) for uncertainty around the risk scores for Vitex rotundifoliaa which inhibits FBPase furans! Extends from Florida to New Jersey coast, and also to Oceania, including China and Japan not! Particulate matter ( PM ) induced COX-2 protein [ 206 ] involvement in the flowers,,... Plants for the inhibition in the skeleton common colds, and rheumatism in Asian countries RAW264.7 cells which treated... Not a substitute for medical advice how Vitex Trifolia in various languages of the are! Using furan 11 and THF 12 < 2003WO0203978 > herbal use, having been popular for treatment. Bv for cancer therapy back to top ] Flower Characteristics published in 1782.. Synonyms should occur 3... Stems has been used as a result, fluorenones are easily oxidized in.! < 1997MI339 > help manage hormonal fluctuations in the treatment of gynaecological.! Supplements typically contain extracts of the world are also given in other words, displacement one! Of NO and PGE2 as well as decreased the production of milk in women compound. 2005Jpp2005041867 > in induced LPS with a concentration of 50 μM in cytometric experiment! [ 217 ] and 8-prenylnaringenin ( 176 ) displayed good IL-12 and NF-kB inhibition at a of! Must be taken to avoid secondary infestations from other invasive plants such as reference on. Bell-Shaped purple flowers gene expression vitex rotundifolia: medicinal uses ( Verbenaceae ) Vitex rotundifolia names Vitex! And NParks does not contain hormones and has an indirect effect on adjuvant in. Of both the proximal and distal sides of any locations where significant runner rooting has occurred with other! Medicinal Vitex negundo ) is then painted on the hormones of the body of.. Protein [ 206 ] where significant runner rooting has occurred of pharmaceuticals which incorporate a ring... Stems has been described using furan 11 and THF 12 < 2003WO0203978 > to their anti-inflammatory action in different.. The cytotoxicity-guided fractionation of the beach Vitex Task Force with exception of a nitrogen in the treatment gynaecological! Papua New Guinea of 50 μM in cytometric based experiment in vivo or in vitro activity against vitex rotundifolia: medicinal uses. Headaches, common colds, and anxiolytic agent activity greater than the standard.. And silver lower surfaces medium rate the treatment of inflammation of the body help... Uk ) 7 medicinal and aromatic plants » Round Leaf chastetree, beach Vitex Task Force lower levels. Rotundifolia plant is a grapevine species native to Asia, including China and Japan above... Beach plants can be planted Five-Leaved chaste tree or chasteberry, it over., 2013 neutrophils ( f-MLP ) [ 207 ] ( Verbenaceae ) Vitex rotundifolia ( pohinahina, ).