The gel from the leaves of Bulbine natalensis (BN) and Bulbine frutescens (BF) is commonly used as a traditional medicine in South Africa for the treatment of skin wounds and burns. Bulbine natalensis is a plant indigenous to Africa, traditionally used as an aphrodisiac and tonic in tribesmen. Bulbine natalensis is a medicinal herb, selling as natural testosterone booster and widely used for enhancing the male sexual performance.. B. natalensis extracts and its constituents activated PXR and induced mRNA expression of cytochrome P450 genes resulting into an increased activity of CYP3A4 and CYP2C9 enzymes in hepatic cells.. However, the catalytic activity of CYP2C9 was also … What’s more, as mentioned above, one study confirmed the safety of it for the same period of a supplement cycle: four weeks. 1.0) 4 weeks ago I have been fixing and dealing with the issues and constructive criticism the project received on the first post. The incisional wounds were used to test tensile strength of the healed wounds using a tensiometer.In the in vitro studies, neither extract caused cytotoxicity to either the fibroblast or keratinocyte cells. Ethnopharmacological relevance. Despite the herb’s documented benefits and uses in traditional medicine, current studies on B. natalensis are scant. Let’s take a look at what science is saying about this compound, the benefits of it, and whether you should use it to boost testosterone and sex drive. Sports Nutrition Research has also announced that there are plans for The Center for Applied Health Science to conduct more human trials involving ProLensis™ in the future. This can be converted into an estimated 8 mg/kg for a 60 kg human according to the Body Surface Area Conversions standards laid down by the Food and Drug Administration (FDA) [ 15 ]. The aqueous extract of Bulbine natalensis stem at these doses (25 and 50 mg/kg body weight) may be used in the management of disorders of desire/libido, premature ejaculation and erectile dysfunction in males. Editor’s Note: While the potential increase in DHT does not concern me, as noted several times throughout other articles on iTestosterone; I prefer to focus heavily on supplements proven in human based case studies. While Fadogia has been shown in rodent studies to increase testosterone by 100% (doubling your natural test levels! The results are indicative of prosexual stimulatory potentials of Bulbine natalensis in male rats. These findings have since been reproduced in unpublished human studies, and today ProLensis™ features in some of the most popular testosterone-boosting dietary supplements available. For decades in the strength, bodybuilding and sporting world athletes have searched for optimal testosterone production in order to improve performance, add muscle mass, improve recovery or, even aid sexual performance. Treatment with both leaf gel extracts has previously been demonstrated to increase tensile strength and protein and DNA content in pig dermal wounds. It is these plant-based compounds that give Bulbine Natalensis its medicinal properties. Hair Loss: Since Bulbine Natalensis increases testosterone and cholesterol levels, precursors for dihydrotestosterone (DHT) conversion, you do have the risk of hair loss. Bulbine Natalensis Recommended Dosage, Benefits, and Side Effects. The main motive for this project is to organize and put an end to the scatteredness of nootropics-literature and the lack of a single place with only human studies. Bulbine natalensis is a perennial herb indigenous to South Africa that is currently being marketed as a prosexual product for men. What was once tribal knowledge is now getting international attention as studies are revealing the benefits of Bulbine Natalensis. In the only human study with Bulbine natalensis, it was consumed at a dosage of 325 mg twice a day . With that said, the effect from Bulbine Natalensis was so dramatic that researchers concluded Bulbine Natalensis may promote liver side effects that are comparable to a steroid cycle. This is an important finding for ProLensis™ as it provides the first peer-reviewed documentation of safety in humans. Rat studies investigating how bulbine natalensis interacts with testosterone note that 50mg/kg (of a 10:1 extraction) appear to be the optimal dosage, and based on Body Surface Area Conversions, this correlates into an estimated human dose of 8mg/kg or:. Bulbine natalensis is a herb that grows in the southern parts of Africa where it has traditionally been used as an aphrodisiac. Bulbine Natalensis Recommended Dosage, Benefits, & Side Effects In the fitness community, users typically consume Bulbine Natalensis with the goal of increasing testosterone and sex drive. In one study, 25 mg to 50 mg per kilogram of bodyweight of Bulbine Natalensis was shown to increase testosterone levels as well as serum follicle stimulating and luteinizing hormone concentrations. It has also been shown to exhibit potent aphrodisiac qualities. 550mg for a 150lb person. There are very few human studies of the effects of bulbine natalensis, since it is a relatively new health product. Journal of the International Society of Sports Nutrition (JISSN). Bulbine Natalensis and the Importance of Natural Testosterone Production. When he’s not in the gym or on the road, he enjoys reading and salsa dancing. Bulbine Natalensis is a good natural testosterone booster, which greatly influence testosterone level and thus, increase drive and performance. Human studies are needed, however. Bulbine Natalensis is a natural herb that originates from the South and South Eastern parts of Africa. ProLensis™ is a well-studied specific extract of bulbine natalensis, with several animal model studies demonstrating the benefit for controlling the hormones testosterone and estrogen – both hormones involved in body augmentation. The photo shows Bulbine natalensis.Its Zulu name is ibhucu; Afrikaners call it rooiwortel.Herbalists sometimes prescribe the root of the plant for men with impotence problems. The dosing seems, in rats, to have a inverse U relationship to testosterone, a sem linear downwards relationship to estrogen. In my personal opinion, there is no reason to believe a nutrient will provide any specific value to the human body until a human based case study gives reason to be optimistic. ProLensis™ is a well-studied specific extract of bulbine natalensis, with several animal model studies demonstrating the benefit for controlling the hormones testosterone and estrogen – both hormones involved in body augmentation. ... given the significance of the results in all of the studies undertaken so far, there is a strong probability that the effects can be seen in human equivalent doses. Questions about a news article you've read? It’s easy to see why – the effects of extracts of Bulbine natalensis recorded in animal studies are amazing. The question is: Based on research, it is potentially a very dangerous supplement. After 30, a man can expect to lose 1% of his testosterone a year, year on year. While it is far more anabolic and androgenic than testosterone, DHT is thought to be one of the primary reasons for male pattern baldness and hair loss. The African continent has a rich history of medicinal plant use, and a large number of these plants are … The findings were presented at the recent International Society of Sports Nutrition (ISSN) conference held in Clearwater beach, Florida in June 2012. These doses are currently only estimates, but … Stefan Gafner, PhD, ABC’s chief science officer, said: “We are grateful to Afrigetics Botanicals for its adoption of Bulbine natalensis. The very word testosterone produces an image of an “Alpha male” Blood, sweat and cold iron. The Dangers of Bulbine Natalensis. Bulbine Natalensis is a South African shrub that has been used in traditional medicine to treat a variety of conditions including diabetes and convulsions. While this was not the cause of death for the animals, it is of concern because organ shrinkage can lead to organ failure. The prosexual effect of the testosterone booster ProLensis™ (Bulbine natalensis) by John Connor. Bulbine natalensis is quickly gaining popularity in the sports supplement world. There is evidence from the limited studies undertaken on Bulbine Natalensis to suggest that there is a toxic effect, specifically relating to the liver. These studies further suggest that compared to other herbal extracts used for boosting testosterone, Bulbine Natalensis could be the only one with the ability to lower estrogen levels. In two animal-based studies, Bulbine Natalensis was shown to significantly increase testosterone levels. It’s essential to note that except for one all studies analyzing the impacts of Bulbine Natalensis have been performed on rats instead of people. As the first step in a series of experiments designed to assess in the in vivo effects of Bulbine natalensis (ProLensis™) supplementation, we performed a placebo-controlled, double-blind clinical trial to assess the short-term safety of this ingredient. The rodent data suggests a testosterone boost of 347% compared to baseline, while lowering estrogen by 35%. Falling testosterone levels are something all men have to face as they age. Another study mirrored these benefits, confirming the superiority of the 25 mg to 50 mg per kilogram of bodyweight dosage. 730mg for a 200lb person. Bulbine Natalensis is a type of herb from South Eastern and Southern African countries and has been used for years as a form of aphrodisiac and other health benefits. Cell proliferation was greater than 100% at 0.1-5 and 100-300 μg/ml for Bulbine natalensis and at 0.1μg/ml for Bulbine frutescens. This testosterone booster has only recently come to light in Western fitness circles, but demonstrates very positive results so far.. Those rats given 100 mg per kilogram of bodyweight did not see the same results. Questions about your PRWeb account or interested in learning more about our news services? The values investigated by the researchers were clinical labs including renal, hepatic and haematological biomarkers. Unlike hyped supplements such as tribulus (that don't increase testosterone) the South African herb Bulbine Natalensis works and has been shown in studies to increase testosterone by a whopping 347% and crush estrogen by 35%. My recommendation is that if you’re going to use Bulbine Natalensis, be sure to cycle on and off (four weeks on, four weeks off) as you would any fitness supplement. Looking through user reviews, you’ll find that the only common negative complaint is that certain brands didn’t work; there are no reports of any horror-story side effects. Clusters of star-shaped yellow flowers on long thin … Vocus, PRWeb, and Publicity Wire are trademarks or registered trademarks of Vocus, Inc. or Vocus PRW Holdings, LLC. Since my first post (ver. 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