Pharmaceutical supply chains: key issues and strategies for optimisation Nilay Shah∗ Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College of Science, Technology and Medicine, London SW7 2BY, UK Abstract Supply chain optimisation is now a major research theme in process operations and management. the supplier (API Consumer Brands) anticipates that bottle packs will be available after mid-November. "I think we're starting to see that impact on the aviation industry, globally and that's going to have an impact on medicines that we fly into the country from overseas." This can be accessed via the ‘News’ menu, or the ‘Supply Issue … Intervention in market mechanisms in the pricing of medicines and drug reimbursement 5. Subsidy by endorsement is available for patients with long-term conditions who require regular daily dosing for one month or greater and the prescription is annotated accordingly. PHARMAC contracts with device suppliers to ensure our hospitals can buy medical devices at fairer prices. The F-Code or ODS code is the the unique code issued to your pharmacy which identifies you to NHS Prescription Services. Report Quota Issues. Read the Medicines Regulations on the Legislation website(external link)(external link), PHARMAC is not responsible for compliance with the Medicines Regulations. Some pharmacies may still have stock to fill prescriptions, but this will be limited and unevenly distributed across the country. Learn more about who PHARMAC is and our goals. Please report the supply issues using a separate … Find out which types of medical device we have contracted and the ones we're working on, Read and subscribe to our devices newsletter, Working with communities and Māori health providers. If I were writing them now, I think I would keep most, if not all. We have been advised of a supply issue with Glucobay (acarbose) 50 mg and 100 mg tablets. The medicines appearing on this page are just a tiny proportion of all the medicines available to treat New Zealanders. PwC's report discusses how pharma companies must develop different supply chain models for different product types and patient segments, use their supply chains for market differentiation and see the role information plays to drive the flow of products and services. PHARMAC staff also acknowledge the good supply history of Xarelto (10, 15 and 20 mg) prior to this. The HSE says it is not aware of any supply issues regarding the nasal flu vaccine, with Dr Siobhán Ní Bhrianin adding that the flu vaccine is also available through GPs if people have difficultly accessing it through their pharmacy. There are often so many links in the chain that the most resilient, adaptable and successful supply chains must be well coordinated. A leading wholesale pharmacy distributor, A-Plus Corporate explores some of the common supply chain issues that interfere with the operations of the modern pharmacy. API Consumer Brands had originally anticipated that bottle pack of paracetamol would be back in stock from mid-November. Pharmac director of operations Lisa Williams talks to Kathryn about the Covid 19 disrupted manufacturing and supply chain which means some commonly prescribed medications are scarce. There are details about our Board and our expert advisors. Here are the five most pressing issues you need to keep front of mind: Lack of coordination – this is a hefty challenge for such a global industry as pharmaceuticals. Despite there being no … PHARMAC has advised that there are ongoing supply issues with oral contraceptives and we have noted these shortages in previous bulletins. Supply issue Active The supplier (Clinect) has advised PHARMAC that from February 2021 olsalazine 250 mg capsule (Dipentum) will be out of stock long term. Regular deliveries of paracetamol are now arriving in New Zealand. However, officials at all companies noted that damage to roads and the fuel supply made it difficult for employees to travel to work. Capacity issues 3. Medicine notices Ngā pānui rongoā Find the details on supply issues, discontinuations and brand changes. We apologise for any inconvenience this causes. However, most of these have now been exhausted. The supplier is expecting a delivery of bottles mid-December. Read the full decision to award sole supply for paracetamol and ibuprofen. We are working with many suppliers to try to resolve this issue. Last Updated: 25 August 2020. Apply to have a medicine funded for everyone or an individual, Medicine notices (includes supply issues), Brand changes, supply issues and discontinuations, Learn about generic medicines, biosimilars, vaccines and getting your prescription, Order condoms and smoking cessation products. Purpose of the group The group was needed to advise PHARMAC on the hospital medicines needed to look after people in intensive care with COVID-19. How can retail pharmacies overcome those challenges in supply chain management? New Zealand's drug-buying agency funds nearly 1000 medicines and it is reliant on budget availability. Please complete the form(s) below to report any problems experienced by the pharmacy in obtaining drugs due to quota allocation restrictions applied by the wholesalers and/or manufacturers. Learn about PHARMAC's role in medicine supply. Pharmacy Supplies Ltd was established in 1992 as a fragrance wholesaler with a focus on servicing the Irish pharmacy market. Supply issues are constantly in flux – Community Pharmacists will have access to up to date information on availability via wholesalers. PHARMAC funds nearly 1,000 medicines. Check the current consultations, RFPs and tenders. The Pharmaceutical Schedule lists all the medicines funded for New Zealanders. Find out how PHARMAC decides what medicines to fund, how to apply for a medicine to be funded and other questions about medicines you might have. Updated versions of the Supply Issues Information document are now available from the FV Community Pharmacy website along with the Supply Issues Flowchart: Supply Issues Bulletin page. What you need to know about medicines. A shipment of bottles of paracetamol 500 mg tablets was damaged and had to be rejected. Necon and Brevinor 28 were listed to cover a shortage of Norimin (ethinyloestradiol 35 micrograms with norethisterone 500 micrograms). This is affecting tens of thousands of patients and pharmacists and doctors have raised concern. Manufacturing and supply logistics are impacted by: Small volumes of paracetamol are being released to the market. A key issue in 2017 is whether the pharmaceutical industry will rebound from a recent low in new drug approvals. The quota system used by some branded medicine manufacturers to try to restrict the trading of medicines within the European free mar… Maximum of 300 tab on a BSO or rural PSO. Find out which types of medical device we have contracted and the ones we're working on, Read and subscribe to our devices newsletter, Working with communities and Māori health providers. Pharmac is apologising to thousands of women who will be forced to change oral contraceptives because supplies of some pill brands are about to run out. continues to seek alternative brands to support the funded market. This allows time for the remaining stock to go through the supply chain. Pharmacists may annotate the prescription as endorsed where dispensing history supports a long-term condition, up to a maximum of 720. Check the current consultations, RFPs and tenders. Current information on Supply Issue with local Forth Valley advice. Brevinor 28 is also different … The 2.5 mg tablet is already out of stock and the 5 mg and 10 mg tablets are expected to run out by mid to late September. We know that these stock outages are challenging. Consultations, RFPs, tenders and our decisions. How these issues get resolved will have a major impact on the future of pharmacy practice. Our plan to deliver the best health outcomes for New Zealanders, Our strategy to support Pacific people to live healthy lives, Learn more about PHARMAC's role and how we support the health system, Our Board, our senior leaders, and experts, Search for funded medicines and Special Authority forms. Maximum of 300 tab per prescription, which can be waived by endorsement. We have asked pharmacists to dispense acarbose in monthly lots to assist in managing the available stock. Commercial withdrawal 4. We have issued a request for tender (RFT) for the supply of paracetamol in the community and in hospitals. We have been advised of a supply issue with Glucobay (acarbose) 50 mg and 100 mg tablets. Paracetamol will remain on monthly dispensing with restrictions in place for the time being to ensure that every New Zealander will continue to have access to paracetamol. The stock shortage is caused by issues at the manufacturer level. Plus, our team of pharmacy inventory management experts will partner with you to optimize your pharmacy supply chain so you can focus on providing excellent care to your patients. Repeats on any prescriptions dispensed before 9 March for quantities over the maximum will not be subsidised unless endorsed. Our plan to deliver the best health outcomes for New Zealanders, Our strategy to support Pacific people to live healthy lives, Learn more about PHARMAC's role and how we support the health system, Our Board, our senior leaders, and experts, Search for funded medicines and Special Authority forms. Paracetamol remains on allocation throughout the supply chain. Damage to sea and airports also We are aware of an out of stock of the paracetamol in bottles. Now, I want to discuss the future in light of 5 major issues I see facing pharmacy. The lack of bottles has increased the demand for blister packs, exacerbating the problem. We've developed a poster you can use to inform your customers that this is a global issue. Toggle child menu. All Issues. Medicines shortages / supply problems: The following medicines have been reported as being in short supply locally and / or nationally. Some New Zealand pharmacies may run out of funded paracetamol tablets by the end of the month due to global supply issues caused by Covid … Interviews with supply chain officials at affected pharmaceutical companies indicated that most factories were able to restart at least some operations quickly after the storm. You can find this on any pricing authority statement or your prescription submission document (FP34c). According to the Irish Pharmacy Union (IPU), 450,000 doses of the nasal vaccine have been distributed but just a quarter have been administered. We have just notified our decision to award sole supply to 2 new brands of paracetamol. We know that supply issues can occur due to a range of unforeseen events and may be down to a combination of factors including: 1. This, in turn means that a worldwide event such as Covid-19, can heavily impact on supply issues … In March 2020, we restricted the dispensing of paracetamol 500 mg tablets due to global stock issues caused by COVID-19. There are no long-term supply issues with Sertraline (Setrona) tab 50 mg & tab 100 mg. Who to contact. PHARMAC staff note the recent issues with the supply of rivaroxaban and understand that this issue has been resolved. If there is a problem at one of those factories, or a glitch in the transportation system, it is possible for the entire stock of particular medicines to become unavailable for months 2. This can be dispensed all at once. PHARMAC listed Arrow-Sertraline for funding to cover the brief out of stock. We understand that blister packs of paracetamol are available for supply. These are likely to be available in the New Year. In the meantime, the supplier is releasing stock into the supply chain to meet usual demand. PHARMAC: listed all alternative brands that were available to supply the funded market. ... About PHARMAC | Mō Te Pātaka Whaioranga. API Consumer Brands has advised us that they continue to have a supply issue for Pharmacare paracetamol 500 mg tablets. With that strain resurgent in 2019, many are warily eyeing their pharmacy supply chains and hoping they hold up if the worst should happen. Problems obtaining an appliance? Supply remains tight. The supplier has advised that they are expecting delivery by mid November. There are details about our Board and our expert advisors. Supply is disrupted at the active ingredient and finished product level. Information sources to assist in managing supply problems/shortages. Back to Medicine notices; Neostigmine: Supply issue. This, however, is not always an easy task. These are likely to be available in the New Year. The Pharmaceutical Schedule lists all the medicines funded for New Zealanders. We do not anticipate the issue will be fully resolved for several months. This is affecting tens of thousands of patients and pharmacists and doctors have raised concern. Toggle child menu. Brand changes, supply issues and discontinuations. If you have any questions about this supply issue, contact: Douglas Pharmaceuticals on 09 835 0660; PHARMAC enquiry@pharmac.govt.nz SUPPLY ISSUES Covid-19 was likely to have global impacts on medicine manufacture and supply chains for the remainder of 2020 and potentially beyond, she said. Since Monday, all pharmacists have been told by Pharmac to only give patients one month supply … We know supplies remain constrained and we are working with a number of suppliers to try to improve stock levels. Manufacturing issues or disruption 2. Intermittent supply problems can occur due to either manufacturing issues causing shortages of branded products (‘Manufacturer Cannot Supply’, MCS) or supply issues affecting generic medicines, resulting in generics being difficult to obtain at Scottish Drug Tariff Part 7 (SDT) prices, or at all (‘Short Supply… Find the details on supply issues, discontinuations and brand changes. Supply issues with amlodipine PHARMAC have advised that all strengths of the funded brand of amlodipine (Apo-Amlodipine) are in short supply. Check the progress of a medicine funding application. There are a number of obstacles to a smooth-running supply chain: 1. PHARMAC contracts with device suppliers to ensure our hospitals can buy medical devices at fairer prices. "Renewing New Zealand medicines policy and an independent inquiry into Pharmac could address this and other issues raised by stakeholders." PHARMAC understands that there is limited stock of prescription paracetamol tablets at the wholesaler level. How Find our key resources for prescribers, pharmacists, researchers and the public. "We're worried about the impact with the air freight," Fitt said. The funding process. Pharmacists can only dispense one month's funded supply at a time. If you have questions, contact API Consumer Brands: We understand a small number of bottles of paracetamol has been released to the market this week. Zyban (bupropion hydrochloride) 150mg prolonged release tablets - supply disruption Broadcast content: Zyban® (bupropion hydrochloride) 150mg prolonged release tablets will be out of stock from week commencing 15th June 2020 until the end of November 2020. Excessive parallel expor… How funding applications are assessed. Any. Pharmac itself is facing some difficulties with supply issues similar to Australia. Medicine funding and supply. Clark said Pharmac had published comprehensive information about supply issues on its website and encouraged people to contact Pfizer on 0800 736 363 if they had any concerns. Pharmac had growing concerns about maintaining the supply of medicines into New Zealand. Drug Shortages PHARMAC is placing temporary dispensing limits on Government-funded paracetamol from Monday 9 March 2020. “With the outbreak of Covid-19, it’s inevitable that there will be disruptions to supply chains and the first we are This, in turn, means that a worldwide event such as COVID-19 can heavily impact on supply issues as we have no Plan B (despite the wishes of the New Zealand Society of Anaesthetists).” The New Zealand Society of Anaesthetists has previously urged PHARMAC to avoid relying on single suppliers for critical medicines like propofol. Search for funded medicines for hospitals, Additional resources for community and hospital Schedules, For pharmacists and prescribers using the Schedule, Read about our work with contracting medical devices for hospitals. “Pharmac’s model relies heavily on sole supply arrangements with various Pharma companies. PHARMAC funds nearly 1,000 medicines. Increased demand 8. Pharmac is about to ease its restrictions on the amount of medicine that can be dispensed at once, with supply issues easing for most of the drugs. All current dispensing restrictions and endorsements apply to these new brands. "It's a mixture … Consultations, RFPs, tenders and our decisions. At Shelving Design Systems, we’re applying lessons learned in the past to pharmacy design for a better future. PHARMAC has today updated healthcare professionals that paracetamol 500mg tablets for dispensing in pharmacies are in short supply due to global supply issues caused by COVID-19, and work is underway to secure more Any pharmacy having difficulty in obtaining stock should contact their local Alliance Healthcare Customer Services Team. Who to contact. Check the progress of a medicine funding application. If you have questions about this stock issue: email: enquiry@pharmac.govt.nz; call: 0800 660 050 Learn more about who PHARMAC is and our goals. The rise of generic medicines and a globalised supply chain mean some medicines are made only in one or two factories across the world. Supply issue feedback forms. Best Practice Bulletin: Issue 12 Contents Update on oral contraception supply issues and replacement options Be aware of psoriasis exacerbations in people taking bupropion PHARMAC announces new Principal Supply Status "Other countries, such as Australia, do not put all their medicines in one supplier and are not experiencing medicine supply issues on the scale that is now being experienced by New Zealanders." Search for funded medicines for hospitals, Additional resources for community and hospital Schedules, For pharmacists and prescribers using the Schedule, Read about our work with contracting medical devices for hospitals. On 22 July 2020, we listed a few alternate brands of paracetamol tab 500 mg – blister packs. Drug recalls and quality issues 6. There was a temporary supply issue. MSD. Supply of at least four commonly used contraceptive pills is about to run out - leaving many people … Learn about generic medicines, biosimilars, vaccines and getting your prescription. Search for medicines funded in hospitals. Apply to have a medicine funded for everyone or an individual, Medicine notices (includes supply issues), Brand changes, supply issues and discontinuations, Learn about generic medicines, biosimilars, vaccines and getting your prescription, Order condoms and smoking cessation products. In the interest of resiliency, which supply chain issues are most urgent today? We understand that some pharmacies may have run out of funded paracetamol 500 mg tablets. These restrictions remain in place. The primary focus of the healthcare sector is to provide patients with the best quality of care. Some of the drugs affected include : four commonly used contraceptive pills, hormone replacement therapy, an … Please see the following notices regarding supply issues of commonly used anaesthetic drugs. We understand these supplies are now exhausted. The pharmaceutical company Pfizer does not expect them to be back in stock until mid-February next year. The proposed dates for listing the new paracetamol brands are: These are the earliest dates the new supplier could commit to. If I were writing them now, I think I would keep most, if not all. But the drug-funding agency is … +1 909-597-8818 info@aplususapharma.com Search for medicines funded in hospitals. ... Read more about the Brevinor 1/28 supply issue. Find out how PHARMAC decides what medicines to fund, how to apply for a medicine to be funded and other questions about medicines you might have. In 2016, the US Food and Drug Administration’s Center for Drug Evaluation and Research approved 22 new molecular entities (NMEs), which was a 51% drop compared with the 45 NMEs approved in 2015 and the lowest total on NME approvals since 2010 when 21 NMEs were approved. Now, I want to discuss the future in light of 5 major issues I see facing pharmacy. The restrictions remain in place despite the return to all-at-once dispensing on 1 August 2020. read the request for tender to supply ibuprofen and paracetamol, Read the RFT for ibuprofen and paracetamol, Read more about the dispensing restrictions, Read the Medicines Regulations on the Legislation website, COVID-19 border and lockdown restrictions. This allocation is unlikely to be able to fill backorders. Pharmac had growing concerns about maintaining the supply of medicines into New Zealand. "We're worried about the impact with the air freight," Ms Fitt said. Non-stat dispensing still applies. We will delist Lyrica in a few months. "I would like to see Pharmac starting to champion for New Zealand patients, and for access to these medicines – not just saying, we do a job with the budget that we have." 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